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. 2018 Apr 30;11:131. doi: 10.3389/fnmol.2018.00131

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Copyright © 2018 Trostchansky, Mastrogiovanni, Miquel, Rodríguez-Bottero, Martínez-Palma, Cassina and Rubbo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasma levels of AA-derived oxidation products. Plasma samples from non-Tg (white bars) and SOD1^G93A (black bars) mice were obtained before symptoms (day 60), when clinical symptoms appear (day 90) and at later stages of the disease (day 140). LOX- (A–C) and PGHS- (D–F) oxidation products were analyzed by LC–MS/MS. Results correspond to the mean ± SEM, with at least six animals per group. ^∗p < 0.05 SOD1^G93A mice compared to non-Tg mice at day 60; ^∗∗p < 0.05 SOD1^G93A mice compared to non-Tg mice at day 90; and ^#,&p < 0.05 non-Tg mice compared to non-Tg at day 60 or day 90.