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. 2018 Mar 14;293(18):6925–6941. doi: 10.1074/jbc.RA118.002566

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© 2018 Peoples et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 10. — Rescue of OCR and steady-state ATP in adrenergic hormone-deficient embryonic hearts with pyruvate or ribose. A and B, oxygen consumption rates in E11.5 adrenergic hormone-competent (●) and adrenergic hormone-deficient (□) embryonic hearts after addition of pyruvate (■), ribose (♦), and rotenone/antimycin A treatment, expressed as percentage compared with adrenergic hormone-competent control baseline. C, steady-state ATP concentrations in adrenergic hormone-competent and adrenergic hormone-deficient embryonic hearts after addition of pyruvate and ribose. Numerical values below the x axes refer to the number (n) of samples analyzed. Data are represented as a percentage compared with competent controls. One-way analysis of variance was performed with Dunnett's multiple comparison test used to evaluate differences between treated groups and control groups. *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with adrenergic hormone-competent controls. #, p < 0.05; ###, p < 0.001 compared with adrenergic hormone-deficient controls.