Figure 5.

Cladograms showing the phylogenetic distribution of putative N-oxidases related to HpxL and PcxL. A, phylogeny of the 500 closest HpxL homologs. hpxL-containing gene clusters that also contain pepM are highlighted in orange. B, phylogeny of actinobacterial PepM sequences. pepM-containing gene clusters that contain an HpxL homolog are highlighted in orange. HpxL is denoted with a blue asterisk, PcxL is denoted with a purple asterisk, and FzmM is denoted with a pink asterisk. Gene clusters were arbitrarily defined to include the 15 genes upstream or downstream of the N-oxidase.