Figure 8.

Effect of S5 aromatic residue mutation on I_hERG by Cavalli-2. Representative current traces from F557L (A, panel ii) before and after application of 300 nm Cavalli-2 (Cav-2) and its WT control (A, panel i) are shown. B, concentration-response relationships for inhibition of F557L and WT I_hERG tails at −40 mV by Cavalli-2 (n ≥ 5 for each concentration of each curve). C, mean ± S.E. fractional block data for F557L I_hERG tails following voltage commands to −20, 0, +20, and +40 mV. Data are from six cells. Error bars represent means ± S.E.