Table 1.

The effects of different treatments on the onset of clonic seizure induced by the pentylenetetrazole

Treatment	Onset of clonic seizure (median (IQR 25))	Statistics (Dunn’s test)	P value
Opipramol (10 mg/kg)	53.00 (45.50)	14.38†	1.000
Opipramol (20 mg/kg)	77.50 (70.50)	35.94†	0.021*
Opipramol (50 mg/kg)	73.00 (70.25)	31.56†	0.093
Ketamine (50 mg/kg)	45.00 (42.50)	2.81†	1.000
Caffeine (200 mg/kg)	58.00 (56.25)	19.19†	1.000
Opipramol (20 mg/kg)+ketamine (50 mg/kg)	73.50 (65.50)	27.44† 8.50‡ −24.62§	0.313 1.000 0.670
Opipramol (20 mg/kg)+caffeine (200 mg/kg)	77.50 (67.50)	33.69† 2.25‡ −14.50#	0.046* 1.000 1.000
Diazepam (5 mg/kg)	250.00 (250.00)	56.63†	<0.001*
Vehicle	52.00 (36.00)

Drugs were administered interaperitoneally 30 minutes before the injection of pentylenetetrazole. Data presented as median and IQR 25 (inter quartile range 25) and analyzed using Kruskal-Wallis test followed by the Dunn’s test. Each group consisted of 8 animals.

^*P<0.05;

^†Compared with control;

^‡Compared with opipramol (20 mg/kg);

^§Compared with ketamine;

^#Compared with caffeine