Table 2.

The effects of different treatments on the onset of tonic-clonic seizure induced by pentylenetetrazole

Treatment	Onset of tonic-clonic seizure (median (IQR 25))	Statistics (Dunn’s test)	P value
Opipramol (10 mg/kg)	102.500 (63.25)	28.31†	0.084
Opipramol (20 mg/kg)	103.50 (71.25)	30.12†	0.0.43*
Opipramol (50 mg/kg)	88.00 (80.00)	24.19†	0.340
Ketamine (50 mg/kg)	83.00 (63.50)	25.25†	0.240
Caffeine (200 mg/kg)	104.50 (76.25)	25.44†	0.220
Opipramol (20 mg/kg)+ketamine (50 mg/kg)	145.00 (122.50)	41.56† −11.44‡ −16.31§	<0.001 1.000 1.000
Opipramol (20 mg/kg)+caffeine (200 mg/kg)	127.50 (120.00)	40.62† −10.50‡ −15.19#	<0.001 1.000 1.000
Vehicle	60.00 (48.00)

Drugs were administered interaperitoneally 30 minutes before the injection of pentylenetetrazole. Data presented as median and IQR 25 (inter quartile range 25) and analyzed using Kruskal-Wallis test followed by the Dunn’s test. Each group consisted of 8 animals.

^*P<0.05;

^†Compared with control;

^‡Compared with opipramol (20 mg/kg);

^§Compared with ketamine;

^#Compared with caffeine