Table 3.

The effects of different treatments on the time of death of animals challenged with pentylenetetrazole

Treatment	Death time (median (IQR 25))	Statistics (Dunn’s test)	P value
Opipramol (10 mg/kg)	220.00 (122.00)	20.11†	0.940
Opipramol (20 mg/kg)	313.00 (244.00)	33.56†	0.004*
Opipramol (50 mg/kg)	500 (368.75)	39.17†	0.001*
Ketamine (50 mg/kg)	420.00 (270.00)	35.04†	0.004*
Caffeine (200 mg/kg)	160.00 (112.50)	13.88†	1.000
Opipramol (20 mg/kg)+ketamine (50 mg/kg)	600 (277.50)	40.38† −6.81‡ −5.34§	<0.001* 1.000 1.000
Opipramol (20 mg/kg)+caffeine (200 mg/kg)	146.00 (130.00)	12.60† 20.88‡ 1.19#	1.000 1.000 1.000
Vehicle	107.50 (100.75)

Drugs were administered interaperitoneally 30 minutes before the injection of pentylenetetrazole. Data presented as median and IQR 25 (inter quartile range 25) and analyzed using Kruskal-Wallis test followed by the Dunn’s test. Each group consisted of 8 animals.

^*P<0.05;

^†Compared with control;

^‡Compared with opipramol (20 mg/kg);

^§Compared with ketamine;

^#Compared with caffeine