Table 2.

Flow optimization of the coupling of epichlorohydrin 3, with 0.1 M 4-nitrophenol (4) at 1 ml min⁻¹.

epichlorohydrin 3 (M)	residence time (min)	temp (°C)	ratioa,b (4 : 5a : 6a)
6	10	105	16 : 84 : 0
5	10	105	34 : 66 : 0
2.5	10	105	61 : 39 : 0
0.5	10	105	87 : 13 : 0
2.5	20	105	30 : 70 : 0
2.5	20	115	54 : 0 : 46
2.5	20	125	5 : 0 : 95
5	20	105	0 : 100 : 0

^a Reaction conditions: t_r = 10 min (10 ml loop) or 20 min (2 × 10 ml loop), 5 bar.

^bRatios calculated by UPLC-MS analysis.