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Optimized reaction conditions for flow aminolysis of epoxides 5a, 8a and 8b with t-butylamine.
| epoxide | t-butylamine (equiv.) | temp (°C) | pressure (bar) | conversion |
|---|---|---|---|---|
| 5a | 5 | 120 | 5 | 100 : 0 : 0 |
| 10a : 13a : 16a | ||||
| 8a | 5 | 150 | 10 | 80 : 0 : 20 |
| 11a : 14a : 17a | ||||
| 8b | 7 | 150 | 10 | 85 : 15: 0 |
| 12a : 15a : 18a |
