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. 2018 Apr 25;114(8):1858–1868. doi: 10.1016/j.bpj.2018.02.034

Figure 4.

Figure 4

Formation of the L-selectin/FERM heterocomplex in different membrane environments. (A–C) The distance between the centers-of-mass of L-selectin and FERM as a function of simulation time in the membranes composed of (A) 100%POPC, (B) 80%POPC/20%POPS, and (C) 95%POPC/5%PIP2 is shown. (D) Snapshots of the CLS position relative to the membrane surface in the FERM-unbound and FERM-bound states in the PIP2-contained membrane are shown. (E) The distance evolution of the C-terminal bead of CLS from the center layer of the PIP2-contained membrane with (black line) and without (red line) FERM is shown. To see this figure in color, go online.