Figure 6.

Residue analysis revealing contacts between PIP2 and proteins. (A) The distribution of the residues of FERM in contacting PIP2 is given. The two subdomains, consistent with a previous study (49), are denoted by black arrows, and the sequences are shown. (B) Contact maps of the residues of FERM that interact with CLS are shown. The residue number 0–80 is highlighted in the lower figure. The two subdomains are surrounded by the green dashed brackets. (C) A snapshot of the ternary complex of PIP2/FERM/L-selectin is shown. KK₃₆₃ residues are shown as yellow branches. The two subdomains revealed in (B) are shown extra in silver. (D) Contact maps of CLS residues in binding to PIP2 (upper panel) and FERM (lower panel) are shown. The residues concurrently contacting PIP2 and FERM are marked by the green rectangle. To see this figure in color, go online.