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. 2018 Apr 30;12:281. doi: 10.3389/fnins.2018.00281

Figure 2.

Figure 2

Overexpression of DGCR8 does not lead to apoptosis at E14.5 (A–D) Hoechst staining on coronal cryosections through the dorsal telencephalon of Dgcr8 WT (A) and Dgcr8 conditional knockout (cKO) (B) mouse embryos at E12.5 or on coronal cryosections through the dorsal telencephalon of Control (C) and DGCR8 OE (D) mouse embryos at E14.5 after IUEp at E12.5. (A'–D') Immunostaining for activated CASPASE-3 (green) on coronal cryosections through the dorsal telencephalon of Dgcr8 WT (A') and Dgcr8 cKO (B') mouse embryos at E12.5 or on coronal cryosections through the dorsal telencephalon of Control (C') and DGCR8 OE (D') mouse embryos at E14.5 after IUEp at E12.5; electroporated cells (mCherry, red); dashed lines indicate limits of the cortical wall (from outside to inside: NL: neuronal layer, IZ: intermediate zone, SVZ: subventricular zone and VZ: ventricular zone); scale bars: 20 μm (A–B'); scale bar: 100 μm (C–D'). *p-value < 0.05; **p-value < 0.01.