Table 1.
Evaluation of the antidepressant-like activity of DHIPC in the forced swim test
| Compounds |
Dosage
(mg/kg) |
Antidepressant activity
a
|
|
|---|---|---|---|
| Duration of immobility(s) | DID (%) b | ||
| DHIPC | 10 | 89.5 ± 9.8* | 30.46 |
| 20 | 68.9 ± 11.3** | 46.46 | |
| 30 | 53.3 ± 11.3** | 58.59 | |
| fluoxetine | 20 | 55.3 ± 8.1*** | 57.03 |
| Control | — | 128.7 ± 12.7 | — |
a
DHIPC and fluoxetine were administered intraperitoneally. Values are the mean ± SEM (n = 8).
*
Significantly different compared with control (*p < 0.05,
**
p < 0.01
***
p < 0.001
b
% DID: percentage decrease in immobility duration.