Table 6.
GO functional enrichment analysis of up- regulated and down-regulated PPI network modules. Top three terms of each module are tabulated
| Category | Term | Description | |
|---|---|---|---|
| Up regulated | Up-1 | GO:0006396 | RNA processing |
| GO:0000380 | Alternative mRNA splicing | ||
| GO:0071826 | Ribonucleoprotein complex subunit organization | ||
| Up-2 | GO:0000082 | G1/S transition of mitotic cell cycle | |
| GO:0042769 | DNA damage response | ||
| GO:1901992 | Positive regulation of mitotic cell cycle phase transition | ||
| Up-3 | GO:0031398 | Positive regulation of ubiquitination | |
| GO:0046364 | Monosaccharide biosynthetic process | ||
| GO:0006098 | Pentose-phosphate shut | ||
| Up-4 | GO:0008380 | RNA splicing | |
| GO:0022613 | Ribonucleoprotein complex biogenesis | ||
|
|
GO:0031123 |
RNA 3 -end
processing |
|
| Down regulated | Down-1 | GO:0022904 | Respiratory electron transport chain |
| GO:0046034 | ATP metabolic process | ||
| GO:1902600 | Hydrogen transmembrane transport | ||
| Down-2 | GO:1900739 | Regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | |
| GO:0031110 | Regulation of microtubule (de) polymerization | ||
| GO:0016259 | Selenocystein metabolic process | ||
| Down-3 | GO:0010257 | NADH dehydrogenase complex assembly | |
| GO:0006099 | Tricarboxylic acid cycle |