Skip to main content
. Author manuscript; available in PMC: 2018 May 7.
Published in final edited form as: Mod Pathol. 2017 Sep 8;31(1):111–121. doi: 10.1038/modpathol.2017.110

Figure 1.

Figure 1

Example of LCNEC with focal napsin A expression (case ID 16 in Table 2). (A) H&E sections illustrate classic LCNEC morphology, including nested growth pattern with peripheral nuclear palisading, frequent rosette-like arrangements, and areas of geographic necrosis. (B) Higher-power image illustrates non-small cell cytomorphology - moderate volume of cytoplasm and evident nucleoli. Panels C and D illustrate weak and focal but convincing granular cytoplasmic napsin A labeling. Panel E illustrates diffuse labeling for synaptophysin. F. Ki67 marker confirms high proliferation rate (70%).