TABLE 3.
Comparison of napsin A and TTF-1 expression in large cell neuroendocrine carcinoma versus lung adenocarcinoma.
| LCNEC (n=112) | Adenocarcinoma (n=60) | p value | |
|---|---|---|---|
| Napsin A expression | |||
| Napsin-A-positive: n (%) | 17 (15%) | 51 (85%) | 0.0001 |
| Extent of labeling in positive cases: mean±SD | 34±32% | 93±34% | <0.0001 |
| Intensity of labeling in positive cases: mean±SD | 1.4±0.4 | 2.6±1.4 | <0.0001 |
| Napsin A/TTF-1 joint expression* | |||
| Napsin A(+)/TTF-1(+) | 16 (16%) | 51 (85%) | < 0.0001 |
| Napsin A(−)/TTF-1(+) | 47 (44%)1 | 2 (3%)2 | |
| Napsin A(+)/TTF-1(−) | 0 | 0 | |
| Napsin A(−)/TTF-1(−) | 43 (41%) | 7 (12%) | |
*
TTF-1 result was not available for 6 LCNECs. SD = standard deviation
1
Extent of TTF-1 expression TTF-1(+) LCNECs was strong/diffuse in most cases.
2
In both cases of Napsin A(−)/TTF-1(+) adenocarcinomas, TTF-1 expression was weak/focal.