Parameter	Description
ppm (Set mass accuracy)	The deviation value should be slightly higher than that of the expected mass accuracy of the instrument. Guidelines are 5–15 p.p.m. for Orbitrap data, ~5 p.p.m. for lock mass quadrupole time of flight (QTOF) data and 10–20 p.p.m. for other QTOF instruments
minimum/maximum peak width	This depends mainly on the type of chromatographic separation performed. For standard reverse-phase separations, a general guideline is 20–60 s, whereas for hydrophilic interaction liquid chromatography (HILIC), in which run times tend to be longer with broader peaks, we recommend 25–90 s. When running with UPLC, these values should drop markedly because of shorter run times and higher resolution, with suggested starting values between 2 and 5 s to a maximum of 30 s. If in doubt of values, check the raw chromatographic run for peak widths of some common compounds from each end of the trace. These values are not hard cutoffs and may be detected slightly out of this range, depending on the quality of the peak data