Table 2.

Diagnostic assays for PD-L1 for anti-PD-1/PD-L1 drugs in non-small cell lung cancer.

	Pembrolizumab			Nivolumab	Atezolizumab
Assay	22C3			28–8	SP142
Indication	1st	1st	2nd	2nd	2nd
PD-L1 required	⩾50%	No	⩾1%	No$	No$
Regimen	Single agent	With chemo*	Single agent	Single agent	Single agent

^*With carboplatin and pemetrexed for adenocarcinomas only.

^$Response is enriched when positive.

PD-1, programmed cell death 1; PD-L1 programmed cell death ligand 1.