Table 3.

The effect of ACEIs and ARBs on cognitive function: Human study.

Study design	Tested drug	Result	Reference
Cross sectional	ACE-Is and ARBs	Reduce cognitive decline	Ellul et al., 2007
Observational	ACEIs	Slow decline of memory and daily functions	Hajjar et al., 2008
Case Control	ACE-Is and ARBs	Decease incidence of AD	Davies et al., 2011
Cohort	ARBs	Reduction in the incidence and progression of AD	Li et al., 2010
Cohort	ACE-Is	Slow cognitive decline	Soto et al., 2013
Observational	RAS-Ms	Slows cognitive decline	Wharton et al., 2015
Observational	CACE-Is	Reduce functional decline	O’Caoimh et al., 2014
Cohort	ACEIs	Not effect on cognitive decline	Zhuang et al., 2016

ACEIs, angiotensin converting enzyme inhibitors; ARBs, angiotensin II Receptor Blockers; RAS-Ms, renin angiotensin system medications; CACE-I, centrally acting Angiotensin converting enzyme inhibitors.