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. Author manuscript; available in PMC: 2018 Jul 17.
Published in final edited form as: Nature. 2018 Jan 17;553(7689):455–460. doi: 10.1038/nature25448

Figure 3. Glutamatergic neurons in the cuneiform nucleus are needed and sufficient for fast synchronous locomotion.

Figure 3

a,b, Injection of DREADDs bilaterally in CnF of Vglut2Cre and probability of evoking gallop/bound before and after inactivation of CnF with CNO during air-puff induced escaping behaviour (p=0.0312, two-tailed sign-rank test, N=6).

c–d, Maximum speeds of locomotion (c) combining inhibitory DREADDs in the PPN, and optogenetic activation of CnF at 50 Hz before (grey, n=13 repetitions, N=4 mice) and after CNO (orange bars, n=12 repetitions, N=4 mice, p<0.05, two-tailed U-test) and their relationship with gaits (d).

Drawing in Fig. 3a reproduced with permission from Mattias Karlen.