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. Author manuscript; available in PMC: 2019 Apr 20.
Published in final edited form as: Org Lett. 2018 Mar 28;20(8):2133–2137. doi: 10.1021/acs.orglett.8b00282

Scheme 4. Aryl Imine Aza-Friedel–Crafts Scopea.

Scheme 4

aReaction conditions: imine (0.20 mmol) and phenol (0.30 mmol) and flame-dried 4 Å mol. sieves were added to a solution of Cu(OTf)2 (0.020 mmol) and (R)-Bn-Box (0.030 mmol) in 1 mL of DCE at 0 °C, and the mixture was stirred 24 h. bAbsolute configuration determined by X-ray crystallography (see SI).