Table 4.
Evaluate Departure from Multiplicity
| Seizure | |||||
|---|---|---|---|---|---|
| Terms in model | MMR (no DTaP) | DTaP (no MMR) | MMR and DTaP | Departure from multiplicity | |
| n | 695 | 646 | 522 | ||
| MMR + DTaP + MMR* DTaP | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | MMR*DTaP Interaction |
p-value |
|
| |||||
| No other adjustment | 2.9 (2.4, 3.5) | 1.2 (0.9, 1.5) | 4.6 (3.8, 5.5) | 1.3 (0.9, 1.9) | 0.124 |
|
| |||||
| Adjusted for concomitant vaccines1 | 3.5 (2.5, 4.8) | 1.2 (0.9, 1.6) | 5.3 (3.9, 7.3) | 1.3 (0.9, 1.9) | 0.237 |
|
| |||||
| Adjusted for concomitant vaccines1 and age2 | 12 mo | 12 mo | |||
| 2.9 (2.1, 4.1) | 3.4 (2.3, 5) | ||||
| 15mo | 15mo | ||||
| 4.3 (3.2, 5.9) | 1.2 (0.9, 1.6) | 4.9 (3.6, 6.8) | 1.0 (0.7, 1.5) | 0.935 | |
| 18mo | 18mo | ||||
| 6.4 (4.4, 9.3) | 7.3 (5.1, 10.3) | ||||
1
all other vaccine groups in the schedule
2
Age in months on date of vaccination included as interaction with MMR