Figure 2.

High concentration hydrogen (HCH) improves brain edema and neurological function in mice with cerebral ischemia/reperfusion (I/R) injury.

Note: (A) Brain water content as an indicator of brain edema (n = 5 per group); (B) Neurological score in different groups (n = 17-18 per group). After 1-hour ischemia and 24-hour reperfusion, the neurological function was assessed, and the brain was harvested for the quantification of water content of different brain structures. Data are expressed as the mean ± SEM, and analyzed by one-way analysis of variance followed by Turkey test. ***P < 0.001, vs. sham group; ^#P < 0.05, ^##P < 0.01, vs. I/R group. HO: I/R + hydrogen/oxygen group; NO: I/R + nitrogen/oxygen group.