Table 2.
Multivariable analysis for prediction of high-grade prostate cancer
| Variable | Estimate | p |
|---|---|---|
| Intercept | −6.1732 | <0.0001 |
| Age | 0.0478 | <0.0001 |
| PSA | 0.2224 | <0.0001 |
| PSA* | −0.2309 | <0.0001 |
| Free:total ratio | −1.4367 | 0.0034 |
| Family history (Yes) | 0.1629 | 0.1662 |
| AUA symptoms score | −0.0860 | <0.0001 |
| AUA symptoms score* | 0.0865 | 0.0004 |
| Race | ||
| Caucasian | −0.1459 | 0.3604 |
| Black | Reference | Reference |
| Other | −0.5789 | 0.0186 |
| Digital rectal exam (Yes) | 0.9149 | <0.0001 |
*
The second PSA and Symptom Score term represent cubic spline terms to allow for the model to not force a linear relationship with those variables.
AUA: American Urological Association; PSA: prostate-specific antigen.