Table 1. Minimum inhibitory concentrations of flubendazole and a series of calcium channel blockers against Cryptococcus, Saccharomyces, Candida and Aspergillus species.
| Genus | Species | Strain | MIC (μg/mL)a | ||||
|---|---|---|---|---|---|---|---|
| FLB | NIF | NIG | FELO | NISO | |||
| Cryptococcus | deuterogattii | R265 | 0.078 | 10 | >40 | 10–20 | 5–20 |
| gattii | WM179 | 0.078 | 5 | >40 | 10 | 10–40 | |
| tetragattii | M391 | 0.078 | 10 | >40 | ≥20 | 40 | |
| neoformans | H99 | 0.078 | 10 | >40 | 10 | 20–40 | |
| Saccharomyces | cerevisiae | S288c | >40 | ≥40 | >40 | >40 | 10 |
| Candida | parapsilosis | ATCC22019 | >40 | >40 | >40 | >40 | 20 |
| albicans | M23 | >40 | >40 | >40 | >40 | 40 | |
| glabrata | M27 | >40 | 20 | >40 | >40 | 10 | |
| glabrata | M63 | >40 | 20 | >40 | >40 | 10 | |
| Aspergillus | fumigatus | ATCC204305 | >40 | >40 | >40 | >40 | 10–20 |
Notes:
MIC ranges are given for compounds with variable results. MICs greater than 40 μg/mL (shaded in grey) indicate where an MIC was not obtained at the highest testing concentration.
FLB, flubendazole; NIF, nifedipine; NIG, niguldipine; FELO, felodipine; NISO, nisoldipine.
a
MICs obtained from four biological replicates each with technical duplicates.