Table 2. Minimum inhibitory and minimum fungicidal concentrations of flubendazole against Cryptococcus species from varied sources.

Species (molecular genotype)	Strain	Source	Geographic origina	MIC (μg/mL)		MFC (μg/mL)
				FLCb	FLBc	FLBc
C. gattii (VGI)	ENV316	Environmental	Australia		0.078	0.156
	PNG14	Clinical	Papua New Guinea		0.078	0.078
	2005/215	Clinical	France		0.078	0.078
	V15/571_103	Veterinary	Australia		0.078	0.078
C. deuterogattii (VGII)	97/170	Clinical	France	64	0.078	0.078
	R265	Clinical	Canada	4	0.078	0.078
	CBS1930	Veterinary	Aruba		0.078	0.078
	ICB184	Environmental	Brazil		0.039	0.039
	14.1431	Veterinary	Australia	32	0.039	0.078
	LA499	Clinical	Columbia	32	0.039	0.039
	V5	Veterinary	Australia	8	0.039	0.078
	03-201073	Clinical	Australia	16	0.078	0.078
C. bacillisporus (VGIII)	VBP62270	Veterinary	Australia		0.078	0.078
	97/427	Clinical	Mexico		0.156	0.313
	WM161	Environmental	USA		0.156	0.156
	B13C	Clinical	Asia		0.078	0.156
C. tetragattii (VGIV)	MMRL3013	Clinical	Africa		0.039–0.156	0.039–0.156
	M250	Clinical	Malawi		0.156	0.156
	WM779	Veterinary	South Africa		0.078	0.078
	MMRL2650	Clinical	India		0.039	0.078
C. neoformans (VNI)	1043.ENR.STOR	Clinical	Africa		0.078	0.156
	1020.CLIN1	Clinical	Africa		0.039	0.078
	H99	Clinical	USA	4	0.039	0.039
	WM625	Clinical	Australia	8	0.02	0.039
	WM385	Clinical	Thailand	4	0.039	0.039
C. neoformans (VNII)	1023.ENR	Clinical	Africa		0.039	0.078
	1045.ENR.STOR	Clinical	Africa		0.078	0.156
C. neoformans (VNBI)	1050.ENR.CLIN	Clinical	Africa		0.078	0.156
C. neoformans (VNBII)	1033.ENR	Clinical	Africa		0.039	0.078
	1052.ENR.STOR	Clinical	Africa		0.039	0.078
	1049.THER1.STOR	Clinical	Africa		0.039	0.039

Notes:

^aUSA, United States of America; FLU, fluconazole.

^bFLC (fluconazole) MIC data obtained from Chong et al. (2010) and Lai et al. (2016).

^cFLB (flubendazole) MICs and MFCs are shown as modes from four biological replicates, each with technical duplicates. A concentration range is given where variable results were obtained.