Table 2. The top 5 enriched gene ontology terms of differentially expressed genes.

Expression	Category	Term	Gene count	Adjust P value
Up-regulated	GOTERM_BP	GO:0030198∼extracellular matrix organization	38	1.01E−13
	GOTERM_BP	GO:0030574∼collagen catabolic process	20	2.87E−11
	GOTERM_BP	GO:0008544∼epidermis development	22	1.23E−10
	GOTERM_BP	GO:0007155∼cell adhesion	52	2.77E−09
	GOTERM_BP	GO:0006508∼proteolysis	54	6.99E−09
	GOTERM_MF	GO:0005509∼calcium ion binding	75	9.53E−12
	GOTERM_MF	GO:0004252∼serine-type endopeptidase activity	38	2.02E−10
	GOTERM_MF	GO:0005198∼structural molecule activity	34	1.58E−08
	GOTERM_MF	GO:0008201∼heparin binding	26	4.01E−08
	GOTERM_MF	GO:0004869∼cysteine-type endopeptidase inhibitor activity	12	1.39E−07
	GOTERM_CC	GO:0006508∼proteolysis	209	5.72E−46
	GOTERM_CC	GO:0005615∼extracellular space	170	4.03E−35
	GOTERM_CC	GO:0005578∼proteinaceous extracellular matrix	44	5.86E−13
	GOTERM_CC	GO:0005887∼integral component of plasma membrane	117	3.75E−10
	GOTERM_CC	GO:0031012∼extracellular matrix	36	2.73E−07
Down-regulated	GOTERM_BP	GO:0097120∼receptor localization to synapse	4	1.02E−04
	GOTERM_BP	GO:0035418∼protein localization to synapse	4	3.36E−04
	GOTERM_BP	GO:0097114∼NMDA glutamate receptor clustering	3	0.001
	GOTERM_BP	GO:0023041∼neuronal signal transduction	3	0.002
	GOTERM_BP	GO:0097119∼postsynaptic density protein 95 clustering	3	0.002
	GOTERM_MF	GO:0008201∼heparin binding	7	0.006
	GOTERM_MF	GO:0005509∼calcium ion binding	16	0.007
	GOTERM_CC	GO:0005578∼proteinaceous extracellular matrix	14	7.32E−06
	GOTERM_CC	GO:0005615∼extracellular space	34	7.77E−06
	GOTERM_CC	GO:0005576∼extracellular region	37	2.11E−06
	GOTERM_CC	GO:0030141∼secretory granule	6	0.001
	GOTERM_CC	GO:0043025∼neuronal cell body	11	0.002

Notes.

BP

biological process

MF

molecular function

CC

cellular component

P value < 0.01 was considered as threshold values of significant difference.