Table 3.

Univariate and multivariate analysis of the clinical characteristics and gene mutations that could be associated with ETE

Characteristics	Univariate analysis		Multivariate analysis
	OR (95% CI) for ETE	p-value	OR (95% CI) for ETE	p-value
Gender (female vs male)	0.840 (0.500–1.412)	0.510	NA	NA
Age (≥55 vs <55 years)	3.008 (1.678–5.391)	<0.001	2.194 (1.117–4.311)	0.023
Tumor size (>1 vs ≤1 cm)	4.762 (2.667–8.474)	<0.001	4.100 (2.257–7.450)	<0.001
Multifocality (yes vs no)	2.510 (1.528–4.123)	<0.001	2.240 (1.309–3.831)	0.003
HT (yes vs no)	1.150 (0.636–2.077)	0.643	NA	NA
BRAF+/TERT−a	1.101 (0.610–1.986)	0.750	NA	NA
BRAF+/TERT+a	13.947 (2.799–69.504)	<0.001	4.831 (0.886–26.332)	0.069

Note:

^aComparisons were performed between the BRAF⁻/TERT⁻ group and each of other two groups (BRAF⁺/TERT⁻, BRAF⁺/TERT⁺).

Abbreviations: ETE, extrathyroidal extension; HT, Hashimoto thyroiditis; OR, odds ratio; NA, not available.