Table 3.
Multivariate stepwise logistic regression analysis for discriminating HCC from ASC, CH, and LC in chronic HBV infection
| Variables | HCC vs ASC
|
HCC vs CH
|
HCC vs LC
|
HCC vs non-HCC
|
||||
|---|---|---|---|---|---|---|---|---|
| P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | |
| Gender | 0.072 | 0.044 | 5.747 (1.078–30.303) | 0.002 | 3.861 (1.608–9.259) | 0.003 | 3.937 (1.704–9.091) | |
| Age (years) | 0.189 | <0.001 | 1.179 (1.088–1.278) | <0.001 | 1.080 (1.045–1.117) | <0.001 | 1.095 (1.062–1.128) | |
| HBeAg (±) | 0.085 | 0.427 | 0.074 | 0.099 | ||||
| (IU/mL, log) | 0.099 | 0.462 | 0.098 | 0.290 | ||||
| ALT (IU/L) | 0.202 | 0.002 | 0.975 (0.960–0.991) | 0.535 | 0.214 | |||
| AST (IU/L) | 0.245 | 0.003 | 1.018 (1.006–1.031) | 0.077 | 0.083 | |||
| Tbil (μmol/L) | 0.758 | 0.849 | 0.052 | 0.111 | ||||
| Albumin (g/L) | <0.001 | 0.628 (0.491–0.803) | 0.560 | 0.135 | 0.266 | |||
| sTim-3 (pg/mL, log) | <0.001 | 48.476 (6.781–346.545) | 0.012 | 6.315 (1.490–26.771) | 0.009 | 2.798 (1.298–6.033) | <0.001 | 4.310 (2.141–8.676) |
Abbreviations: ASC, chronic asymptomatic HBV carrier status; CH, chronic hepatitis; LC, liver cirrhosis; HCC, hepatocellular carcinoma; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HBV, hepatitis B virus; Tbil, total bilirubin; OR, odds ratio; CI, confidence interval; sTim-3, soluble T-cell immunoglobulin and mucin domain containing molecule-3.