Table 4.
Univariate and multivariate analysis of factors associated with the overall survival of patients with HBV-related hepatocellular carcinoma
| Variables | No of patients | Overall survival (%)
|
Univariate analysis
|
Multivariate analysis
|
|||
|---|---|---|---|---|---|---|---|
| 1 year | 3 years | 5 years | P-value | P-value | HR (95%CI) | ||
| Gender | 0.428 | 0.017 | 4.329 (1.297–14.492) | ||||
| Male | 69 | 73.9 | 24.6 | 5.8 | |||
| Female | 15 | 80.0 | 13.3 | 6.6 | |||
| Age (years) | 0.150 | 0.205 | |||||
| ≤55 | 43 | 82.9 | 24.4 | 7.3 | |||
| >55 | 41 | 67.4 | 20.9 | 2.3 | |||
| HBV DNA (IU/mL) | 0.302 | 0.626 | |||||
| ≤104 | 20 | 90.0 | 25.0 | 5.0 | |||
| >104 | 64 | 70.3 | 21.9 | 4.7 | |||
| ALT (IU/L) | 0.291 | 0.730 | |||||
| ≤40 | 27 | 85.2 | 25.9 | 3.7 | |||
| >40 | 57 | 70.2 | 21.1 | 5.3 | |||
| AST (IU/L) | 0.034 | 0.327 | |||||
| ≤40 | 18 | 94.4 | 44.4 | 11.1 | |||
| >40 | 66 | 69.7 | 16.7 | 3.0 | |||
| Tbil (μmol/L) | 0.002 | 0.568 | |||||
| ≤40 | 55 | 81.8 | 29.1 | 5.5 | |||
| >40 | 29 | 62.1 | 10.3 | 3.5 | |||
| ALB (g/L) | 0.034 | 0.383 | |||||
| ≥35 | 33 | 84.8 | 33.3 | 9.1 | |||
| <35 | 51 | 68.6 | 15.7 | 2.0 | |||
| AFP (ng/mL) | 0.003 | <0.001 | 3.388 (1.816–6.321) | ||||
| <200 | 46 | 89.1 | 34.8 | 8.7 | |||
| ≥200 | 38 | 57.9 | 7.9 | 0.0 | |||
| Platelet count (×109/L) | 0.776 | 0.582 | |||||
| ≤50 | 15 | 73.3 | 20.0 | 0.0 | |||
| >50 | 69 | 75.4 | 23.2 | 5.8 | |||
| MELD score | 0.671 | 0.827 | |||||
| ≤20 | 22 | 77.3 | 25.8 | 6.5 | |||
| >20 | 62 | 74.2 | 13.6 | 4.5 | |||
| Child–Pugh grade | 0.012 | 0.380 | |||||
| A | 45 | 88.9 | 33.3 | 4.4 | |||
| B+C | 39 | 59.0 | 10.3 | 5.1 | |||
| Tumor size (cm) | 0.260 | 0.889 | |||||
| <5 | 33 | 81.8 | 24.2 | 6.1 | |||
| ≥5 | 51 | 70.6 | 56.9 | 3.9 | |||
| TNM stage | 0.054 | 0.622 | |||||
| I+II | 35 | 82.9 | 28.6 | 8.6 | |||
| III+IV | 49 | 69.4 | 18.4 | 2.0 | |||
| sTim-3 (pg/mL) | 0.022 | 0.002 | 2.773 (1.474–5.219) | ||||
| ≤3000 | 33 | 87.9 | 33.3 | 9.1 | |||
| >3000 | 51 | 66.7 | 17.7 | 2.0 | |||
Abbreviations: HBV, hepatitis B virus; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Tbil, total bilirubin; ALB, albumin; AFP, α-fetoprotein; HR, hazard ratio; CI, confidence interval; sTim-3, soluble T-cell immunoglobulin and mucin domain containing molecule-3; TNM, tumor, node, and metastasis; MELD, model for end-stage liver disease.