Figure 1.

Imaging of intranasal delivery of (A) conventional liquid spray (radiolabeled diethylene triamine pentaacetic acid) vs (B) powder (radiolabeled lactose) with the breath-powered device and (C) quantification of deposition patterns.

Notes: Gamma camera image information (logarithmic hot iron intensity scale) from the nasal cavity is superimposed on the corresponding sagittal magnetic resonance imaging section. The image represents deposition 2 minutes after delivery. The images were from the same subject after each method of administration, which were representative of the overall findings from the seven patients included in the study. Panel C shows the percentage distribution by nasal region 0–2 minutes after administration (bars are mean ± SD). Republished with permission of Mary Ann Liebert Inc., from Djupesland PG, Skretting A. Nasal deposition and clearance in man: comparison of a bidirectional powder device and a traditional liquid spray pump. J Aerosol Med Pulm Drug Deliv. 2012;25(5):280–289 permission conveyed through Copyright Clearance Center, Inc.25