Relative liver weight and bile flow in male and female WT mice. Corn oil (vehicle) or TCDD (37 μg/kg) was administered daily (IP) for 4 days to male and female mice (at least 6 mice per treatment group). On the 5th day, livers and bile were collected. Liver weight is expressed as a percent of body weight (BW) (top). Bile flow rates were normalized to BW (middle) and liver weight (bottom). Bars represent means ± SE of mice per group. Asterisks indicate significant difference (p < 0.05) from the respective value of the WT mice. Females (F), males (M), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), wild-type mice (WT). Color image is available in the online version of the article.