Table 2.

Colistin and fosfomycin dosage regimens, PK/PD index values, and sampling times in the in vitro PK/PD model.

Treatment regimen	PK/PD index value												Sampling times (h) for microbiological measurements
	fAUC/MIC				fCmax/MIC				fT > MIC
	Kp47	Kp79	Kp42	Kp11	Kp47	Kp79	Kp42	Kp11	Kp47	Kp79	Kp42	Kp11
Colistin monotherapy, target concentration C max /C min  (mg/L)													0, 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24
0.5/0.14	11.38	5.69	22.76	45.52	1	0.5	2	4	0	0	100	100
2/0.54	44.92	22.46	89.84	179.68	4	2	8	16	100	18.75	100	100
5/1.36	113.82	56.91	227.64	455.28	10	5	20	40	100	100	100	100
Fosfomycin monotherapy, target concentration C max /C min  (mg/L)													0, 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24
100/14.58	837.26	52.33	<3.27	<3.27	100	6.25	<0.39	<0.39	100	100	0	0
Combination therapy													0, 1, 2, 4, 6, 8, 10, 12, 14, 16, 20, 24