(a).

Study/year	Country	Intervention length	Population	Setting	Sources of anthocyanin	Sample size		Design	Anthocyanin dose	TC, mg/dL (mean ± SD)		TG, mg/dL (mean ± SD)		LDL, mg/dL (mean ± SD)
						Anthocyanin	Placebo			Anthocyanin	Placebo	Anthocyanin	Placebo	Anthocyanin	Placebo
Yang et al., 2017 [10]	China	12 wk	Untreated diabetes	O	Capsule Medox (17 natural anthocyanins)	80	80	R, D, P	80 mg	236.27 ± 46.01	232.79 ± 46.40	152.34 ± 90.34	153.23 ± 109.83	131.09 ± 35.19	127.61 ± 34.03
Zhang et al. 2016 [11]	China	Wk (12, 24)	Hypocholesterolemic	I	Capsule	73	73	R, D, P	320 mg	249.42 ± 39.44	250.58 ± 32.48	-	-	129.93 ± 22.43	127.22 ± 18.17
Zhang et al., 2015 [12]	China	12 wk	Nonalcoholic fatty liver disease	I	Bilberry, black current	74	74	R, D, P	80 mg	206.5 ± 30.5	223.9 ± 50.27	155.8 ± 167.7	166.4 ± 177.1	124.1 ± 20.88	134.18 ± 36.34
Li et al., 2015 [13]	China	24 wk	Diabetic	I	Capsule Medox (17 natural anthocyanins)	29	29	R, D, P	80 mg	196.06 ± 34.42	194.51 ± 30.16	180.68 ± 36.31	178.91 ± 31.89	122.58 ± 13.53	123.36 ± 16.24
Davinelli et al., 2015 [14]	Italy	4 wk	Smokers	O	Capsule (Maqui berry extract)	16	26	R, D, P	273.5 mg	167.83 ± 21.27	168.21 ± 17.40	117.80 ± 58.46	119.57 ± 86.80	105.97 ± 37.51	106.34 ± 34.03
Lynn et al., 2014 [15]	UK	6 wk	Healthy adult	O	Tart cherry juice	25	21	R, D, P	162 mg	164.35 ± 30.55	145.40 ± 25.91	-	-	-	-
Soltani et al., 2014 [17]	Iran	4 wk	Hyperlipidemic patients	I	Fresh ripe berries of V. arctostaphylos	25	25	R, D, P	90 mg	226.48 ± 32.09	220.20 ± 45.76	226.20 ± 96.99	226.20 ± 96.99	132.80 ± 23.76	121.0 ± 32.06
Hassellund et al., 2013 [18]	New York	12 wk	Prehypertensive men	I	Bilberry, black current	26	26	R, D, P	500 mg	-	-	-	-	-	-
Zhu et al., 2013 [19]	China	24 wk	Hypocholesterolemic	O	Anthocyanin rich foods	73	73	R, D, P	320 mg	249.42 ± 39.44	250.58 ± 32.48	-	-	129.93 ± 22.43	127.22 ± 18.17
Zhu et al., 2011 [20]	China	12 wk	Hypocholesterolemic	O	Bilberry, black current	73	73	R, D, P	320 mg	249.6 ± 39.5	250.8 ± 32.5	-	-	130 ± 22.4	127.3 ± 18.2
Dohadwala et al., 2011 [21]	Boston	4 hr	Coronary artery disease	I	Cranberry juice	22	22	R, D, P	94 mg	158 ± 39	157 ± 42	130 ± 57	136 ± 56	89 ± 33	89 ± 36
Basu et al., 2010 [22]	Oklahoma	8 wk	Metabolic syndrome	I	Bilberry	25	22	R, D, P	320 mg	-	-	-	-	-	-
Mu et al., 2010 [23]	China	12 wk	Hyperlipidemic patients	I		30	28	R, P	200 mg	226.6 ± 35.2	223.1 ± 30.9	187.7 ± 69.1	215.2 ± 128.4	163.9 ± 32.5	158.2 ± 37.9
Curtis et al., 2009 [24]	UK	12 wk	Healthy women	I	Elderberry	26	26	R, D, P	500 mg	208.82 ± 27.07	212.69 ± 23.20	79.71 ± 26.57	79.71 ± 26.57	131.48 ± 23.20	135.35 ± 23.20
Qin et al., 2009 [25]	China	12 wk	Dyslipidemic patients	I	Capsule Medox (17 natural anthocyanins)	60	60	R, D, P	80 mg	226.2 ± 35.5	224.3 ± 36.4	197.9 ± 87	205.8 ± 83	159.2 ± 34.4	158.5 ± 37.8
Qin and Wenhua 2008 [26]	China	45 days	Hyperlipidemic patients	I	Black rice	51	51	R, P	200 mg	215.8 ± 30.5	210.8 ± 28.2	206.3 ± 91.2	209.9 ± 89.3	-	-
Karlsen et al., 2007 [27]	Norway	3 wk	Healthy adults	O	Capsule Medox (17 natural anthocyanins)	59	59	R, D, P	300 mg	-	-	-	-	-	-