(b).
| Study/year | Country | HDL, mg/dL (mean ± SD) | Apolipoprotein A-1, mg/dL (mean ± SD) | Apolipoprotein B, mg/dL (mean ± SD) | Serum TNF-a, pg/mL | Serum IL-6, pg/mL | Serum hs-CRP, mg/L | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Anthocyanin | Placebo | Anthocyanin | Placebo | Anthocyanin | Placebo | Anthocyanin | Placebo | Anthocyanin | Placebo | Anthocyanin | Placebo | ||
| Yang et al., 2017 [10] | China | 56.84 ± 14.69 | 56.46 ± 13.15 | 160 ± 32 | 165 ± 30 | 116 ± 24 | 114 ± 25 | 1.90 ± 1.97 | 2.2 ± 2.87 | ||||
| Zhang et al. 2016 [11] | China | 47.18 ± 8.89 | 47.95 ± 8.12 | - | - | - | - | 18.4 ± 5.6 | 18.5 ± 5.4 | - | - | 1.74 (0.86–2.6) | 2.19 (0.93–3.82) |
| Zhang et al., 2015 [12] | China | 52.98 ± 10.44 | 51.8 ± 13.5 | - | - | - | - | - | - | - | - | - | - |
| Li et al., 2015 [13] | China | 39.83 ± 4.25 | 37.90 ± 3.09 | 133 ± 32 | 135 ± 24 | 97 ± 20 | 95 ± 17 | 14.8 ± 2.13 | 15.9 ± 2.67 | 2.21 ± 0.42 | 3.18 ± 0.63 | ||
| Davinelli et al., 2015 [14] | Italy | 42.15 ± 39.44 | 40.2 ± 37.5 | - | - | - | - | - | - | - | - | 1.26 ± 1.3 | 1.13 ± 0.98 |
| Lynn et al., 2014 [15] | UK | - | - | - | - | - | - | - | - | - | - | - | - |
| Soltani et al., 2014 [17] | Iran | 45.76 ± 9.73 | 46.56 ± 10.52 | - | - | - | - | - | - | - | - | 2.53 ± 2.33 | 2.80 ± 2.35 |
| Hassellund et al., 2013 [18] | New York | - | - | - | - | - | - | - | - | - | - | - | - |
| Zhu et al., 2013 [19] | China | 47.18 ± 8.89 | 47.95 ± 8.12 | - | - | - | - | 18.7 ± 6.4 | 18 ± 6.0 | - | - | - | - |
| Zhu et al., 2011 [20] | China | 47.2 ± 8.9 | 48 ± 8.1 | 130 ± 16.9 | 133 ± 14.6 | 126 ± 28.4 | 121 ± 26 | - | - | - | - | - | - |
| Dohadwala et al., 2011 [21] | Boston | 43 ± 10 | 41 ± 9 | - | - | - | - | - | - | - | - | 3.1 ± 5.5 | 5.2 ± 9.9 |
| Basu et al., 2010 [22] | Oklahoma | - | - | - | - | - | - | - | - | - | - | - | - |
| Mu et al., 2010 [23] | China | 45.2 ± 8.5 | 46.0 ± 9.3 | - | - | - | - | - | - | - | - | - | - |
| Curtis et al., 2009 [24] | UK | 61.87 ± 15.47 | 61.87 ± 11.60 | - | - | - | - | 15.3 ± 11.1 | 14.8 ± 9.3 | 1.0 ± 0.9 | 1.0 ± 1.4 | 1.3 ± 1.0 | 0.9 ± 0.9 |
| Qin et al., 2009 [25] | China | 45.9 ± 8.5 | 46.1 ± 9.6 | 125.7 ± 17.4 | 124.9 ± 19.5 | 110.8 ± 21.8 | 111.9 ± 24 | - | - | - | - | - | - |
| Qin and Wenhua 2008 [26] | China | 46.4 ± 10.8 | 49.5 ± 9.3 | - | - | - | - | - | - | - | - | - | - |
| Karlsen et al., 2007 [27] | Norway | - | - | - | - | - | - | - | - | −5.9 ± 12.8 | −9.3 ± 19.5 | - | - |
TC: total cholesterol, TG: triglyceride, LDL: low density lipoprotein, HDL: high density lipoprotein, O: outpatients, I: outpatients, R: randomized, D: double blind, and P: parallel trial.