Figure 2.

Effects of hypoxia and PGF on the proliferation of ARPE-19 cells. A: Hypoxia exposure decreased the proliferation rate of ARPE-19 cells, *p<0.05 versus the control group. B: Exogenous placental growth factor (PGF) did not affect the proliferation rate of the ARPE-19 cells. C: Exposure to hypoxia (treatment with CoCl₂ for 12 h) and the addition of exogenous PGF for 48 h increased the proliferation rate of the ARPE-19 cells; *p<0.05 versus the hypoxia group (treatment of CoCl₂ for 12 h). Exposure to hypoxia decreased the proliferation rate of the ARPE-19 cells; #p<0.05 versus the control group. Data are the mean ± standard deviation (SD) of three independent experiments.