TABLE 3.

Univariate and multivariable analyzes of predictors of “no hepatocellular carcinoma on explant”

Predictor variables	Odds ratio (95% CI)	P-value
Univariate analysis
Age
<50 vs ≥50	16.88 (7.49–38.00)	<.001
<55 vs ≥55	5.83 (2.78–12.21)	<.001
<60 vs ≥60	2.66 (1.2–5.74)	.01
Female gender	2.40 (1.18–4.91)	.02
African American (vs Caucasian)	2.64 (1.03–6.78)	.04
Non-hepatitis C etiology (vs hepatitis C)	6.52 (2.63–16.20)	<.001
Child-Pugh score (per point)	0.90 (0.76–1.07)	.22
MELD score (per point)	1.02 (0.94–1.10)	.69
AFP at listing
<5 vs ≥5	3.21 (1.57–6.56)	.001
<10 vs ≥10	4.61 (1.86–11.43)	<.001
<20 vs ≥20	7.10 (1.67–30.26)	.008
Tumor burden at listing
1 lesion 3–5 cm (vs 1 lesion 2–2.9 cm)	0.77 (0.25–2.35)	.64
2 lesions (vs 1 lesion 2–2.9 cm)	0.99 (0.42–2.37)	.99
3 lesions (vs 1 lesion 2–2.9 cm)	1.54 (0.41–5.74)	.52
Median total tumor diameter <3 vs ≥3 cm	1.21 (0.56–2.61)	.64
Wait time from listing to LT
>3 vs ≤3 mo	1.28 (0.62–2.62)	.50
>6 vs ≤6 mo	1.14 (0.41–3.11)	.81
>12 vs ≤12 mo	1.69 (0.36–8.05)	.51
UNOS regiona
Region 2 vs all other regions	1.20 (0.40–3.66)	.75
Region 3 vs all other regions	1.74 (0.85–3.59)	.13
Region 10 vs all other regions	0.50 (0.15–1.69)	.26
Region 11 vs all other regions	0.24 (0.06–1.01)	.052
Multivariate analysis
Age <50 vs ≥50	17.30 (6.99–42.83)	<.001
Non-hepatitis C etiology (vs hepatitis C)	5.43 (1.94–15.20)	.001
AFP <10 vs ≥10	2.87 (1.02–8.06)	.04

^aOnly analyzed individual regions who had at least 20 patients of the entire cohort.