Table 4.
Comparison of baseline pulmonary function tests results using RTOG and CTCAE scales
| RTOG Scale* | CTCAE Scale* | |||||
|---|---|---|---|---|---|---|
| Variable | No pneumonitis (n = 26) | Pneumonitis (n = 11) | P value | No pneumonitis (n = 22) | Pneumonitis (n = 15) | P value |
| median (p25, p75) | median (p25, p75) | median (p25, p75) | median (p25, p75) | |||
| Spirometry | ||||||
| FEV1 post (% predicted value) | 98 (84, 110) | 73 (60, 92) | 0.02 | 98 (86, 110) | 83 (61, 100) | 0.02 |
| FVC post (% predicted value) | 106 (90, 114) | 91 (79, 114) | 0.17 | 109 (90, 116) | 93 (79, 105) | 0.06 |
| FEV1/FVC post (%) | 77 (72, 81) | 65 (54, 74) | 0.01 | 75 (70, 82) | 70 (58, 79) | 0.07 |
| Plethysmography | ||||||
| TLC (L) | 5.1 (4.4, 6.3) | 6.8 (4.8, 6.9) | 0.06 | 5.5 (4.7, 6.3) | 5.5 (4, 6.9) | 0.93 |
| TLC (% predicted value) | 101 (88, 111) | 102 (94, 113) | 0.63 | 103 (95, 113) | 99 (86, 111) | 0.25 |
| RV/TLC (%) | 39 (35, 44) | 50 (38, 59) | 0.01 | 38 (34, 44) | 45 (38, 56) | 0.02 |
| Impulse oscillometry | ||||||
| Rrs5 (Kpa/L/s) | 0.34 (0.29, 0.41) | 0.33 (0.28, 0.44) | 0.98 | 0.34 (0.29, 0.42) | 0.33 (0.28, 0.4) | 0.63 |
| Rrs20 (Kpa/L/s) | 0.26 (0.22, 0.31) | 0.27 (0.2, 0.31) | 0.71 | 0.27 (0.22, 0.32) | 0.26 (0.21, 0.29) | 0.47 |
| Xrs5 (Kpa/L/s) | −0.13 (−0.17, −0.1) | −0.13 (−0.17, −0.082) | 0.64 | −0.13 (−0.17, −0.1) | −0.13 (−0.17, −0.09) | 0.67 |
| AX (Kpa/L) | 0.55 (0.45, 1.3) | 0.81 (0.4, 1.2) | 0.88 | 0.55 (0.45, 1.3) | 0.67 (0.47, 1.2) | 0.77 |
| Carbon Monoxide Diffusing Capacity | ||||||
| DLCO (mL/min/mmHg) | 20 (17, 24) | 16 (10, 19) | 0.06 | 22 (18, 25) | 16 (12, 19) | 0.02 |
| DLCO (% predicted value) | 91 (76, 110) | 66 (51, 98) | 0.06 | 92 (76, 111) | 71 (58, 98) | 0.049 |
| Molar mass of carbon dioxide | ||||||
| PO2 (mmHg) | 66 (61, 69) | 60 (52, 68) | 0.14 | 67 (61, 70) | 60 (57, 68) | 0.07 |
| pCO2 (mmHg) | 29 (27, 31) | 31 (26, 34) | 0.17 | 30 (25, 32) | 29 (27, 33) | 0.65 |
| SO2 (%) | 92 (91, 94) | 92 (87, 94) | 0.32 | 92 (91, 94) | 92 (87, 94) | 0.21 |
| Six-minute walk | ||||||
| Distance (m) | 487 (379, 510) | 429 (367, 481) | 0.16 | 495 (369, 510) | 435 (404, 482) | 0.34 |
| Fraction of exhaled nitric oxide | ||||||
| FENO | 15 (10, 18) | 24 (19, 53) | 0.01 | 15 (11, 18) | 23 (16, 30) | 0.04 |
FEV Forced expiratory volume, FVC Forced vital capacity, FEV1, forced expiratory volume in one second, TLC Total lung capacity, RV Residual volume, Rrs5 Resistance at 5 Hz, Rrs20 Resistance at 20 Hz, Xrs5 Reactance at 5 Hz, AX Reactance Area, DLCO Diffusing capacity of the lung for CO, FeNO Fraction of exhaled Nitric Oxide. * Wilcoxon rank-sum test for unmatched data was used to compare respiratory variables
Significant P values in bold