Table II.
TLR pathway genes differentially expressed in stimulated NZB vs B6 B cells
| Genea | Ratio NZB:B6 |
|---|---|
| Ptpn22 | 4.0 |
| Tlr8 | 3.1 |
| Tlr4 | 2.5 |
| Nfkbie | 2.0 |
| IL6 | 0.5 |
a
Shown are differences ≥ 2.0-fold in either direction
Other genes with expression differences between stimulated NZB and B6 B cells ranging from 1.5 < 2.0 fold in either direction (ratio NZB:B6 shown): Cd14 (1.9), Fn1 (0.6), Il11 (1.8), Irak2 (1.5), Ly96 (1.7), Map2k3 (1.5), Map3k7 (1.6), MyD88 (1.8), Tbc1d10c (1.95), Tirap (1.8), Tlr2 (1.7), Traf3 (1.6)
Genes investigated showing no difference (<1.5-fold): Becn1, c-Cbl, Cbl-b, Ccl11*, Ccl20*, Chuk, Cxcl10, Egr2, Ifnb1*, Ikbkb, Il4*, Irak1, Irak3, Irak4, Jun, Lbp*, Nfkb1, Nfkb2, Nfkbia, Nfkbib, Rel, Rela, Sftpa1*, Tlr1, Tlr5*, Tlr9, Traf6; *expression in these cells was too low to accurately measure.