Table 1.
Primary particle size distributions of the adenosine receptor agonist formulations
| X10 (μm) | X50 (μm) | X90 (μm) | FPF< 5 μm (%) | |
|---|---|---|---|---|
| Spray-dried | ||||
| Adenosine | 1.03 | 2.19 | 3.97 | 96.7 |
| AMP | 0.83 | 2.25 | 4.84 | 91.2 |
| Micronised | ||||
| Adenosine | 0.66 | 1.42 | 2.93 | 100 |
| AMP | 0.65 | 1.40 | 3.38 | 100 |
| CPA | 0.66 | 1.42 | 3.03 | 100 |
X10, X50 and X90 represent the 10, 50 and 90% values from the cumulative volume undersize curve; the X50 value equals the volume median diameter (VMD). Data obtained with RODOS dispersion at 3 bar. n = 2, only the mean is shown because the variation is very low
AMP adenosine 5′-monophosphate, CPA 6 N-cyclopentyladenosine, FPF< 5 μm fine particle fraction <5 μm as percentage of the delivered dose