Table 2.

Plasma proteins associated with plasma log₂ β-carotene in 6–8 year old children of rural Nepal (n = 497).^a

Gene Name	Gene Symbol	nb	r	R2	p	q	b1c	gi Accession Numberd
Orosomucoid 1	ORM1	497	−0.7	0.49	6.07 × 10−5	2.60 × 10−2	−33.0	167857790
Apolipoprotein A-I	APOA1	497	0.7	0.49	6.28 × 10−5	2.60 × 10−2	94.1	4557321
Pyruvate kinase, muscle	PKM	55	−0.65	0.42	1.78 × 10−4	4.94 × 10−2	−67.7	33286422
TNFAIP3 interacting protein 1	TNIP1	385	−0.69	0.48	1.79 × 10−4	4.94 × 10−2	−35.6	116256481

^aFour proteins quantified by mass spectrometry and estimated by linear mixed effects (LME) modelling in >10% of the samples (50 < n ≤ 497) that are correlated with plasma log₂ β-carotene, subjected to a false discovery rate (FDR) cutoff of 10% (q < 0.10), and listed in increasing order of q, defined as candidate protein biomarkers for a plasma β-carotene proteome.

^bn represents the number of child plasma samples in which a protein was detected and quantified by iTRAQ MS.

^cb₁ represents the percent change in plasma β-carotene, (in μmol/L) per 2-fold (100%) increase in protein relative abundance.

^dGenInfo Identifier sequence number, as assigned to all nucleotide and protein sequences by the National Center for Biotechnology Information at the National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.