Table 5.
Plasma proteins negatively associated with plasma log2 β-cryptoxanthin in 6–8 year old children of rural Nepal (n = 500).a
| Gene Name | HUGO Gene Symbol | nb | R | R2 | p | q | b1c | Accession Numberd |
|---|---|---|---|---|---|---|---|---|
| Orosomucoid 1 | ORM1 | 500 | −0.50 | 0.25 | 1.60 × 10−6 | 8.04 × 10−4 | −41.5 | 167857790 |
| TNFAIP3 interacting protein 1 | TNIP1 | 388 | −0.50 | 0.25 | 2.18 × 10−6 | 8.22 × 10−4 | −46.3 | 116256481 |
| Mannosidase, alpha, class 1A, member 1 | MAN1A1 | 500 | −0.50 | 0.25 | 4.17 × 10−5 | 5.71 × 10−3 | −66.0 | 24497519 |
| Haptoglobin | HP | 354 | −0.53 | 0.28 | 6.94 × 10−5 | 8.06 × 10−3 | −13.7 | 4826762 |
| Alpha-1-B glycoprotein | A1BG | 500 | −0.50 | 0.25 | 8.04 × 10−5 | 8.66 × 10−3 | −67.1 | 21071030 |
| Haptoglobin-related protein | HPR | 431 | −0.52 | 0.27 | 1.83 × 10−4 | 1.51 × 10−2 | −22.0 | 45580723 |
| Leucine-rich alpha-2-glycoprotein 1 | LRG1 | 500 | −0.49 | 0.24 | 2.76 × 10−4 | 1.69 × 10−2 | −37.0 | 16418467 |
| Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | SERPINA3 | 500 | −0.49 | 0.24 | 5.42 × 10−4 | 2.43 × 10−2 | −49.1 | 50659080 |
| Orosomucoid 2 | ORM2 | 500 | −0.49 | 0.24 | 6.37 × 10−4 | 2.43 × 10−2 | −41.3 | 4505529 |
| Leucine rich repeat containing 47 | LRRC47 | 70 | −0.51 | 0.26 | 7.35 × 10−4 | 2.64 × 10−2 | −75.0 | 24308207 |
| Complement factor B | CFB | 500 | −0.49 | 0.24 | 1.08 × 10−3 | 3.59 × 10−2 | −46.1 | 67782358 |
| Beta-2-microglobulin | B2M | 493 | −0.49 | 0.24 | 1.28 × 10−3 | 4.10 × 10−2 | −32.7 | 4757826 |
| Ecotropic viral integration site 5 | EVI5 | 271 | −0.54 | 0.29 | 1.58 × 10−3 | 4.95 × 10−2 | −34.6 | 68299759 |
| Ubiquitin-conjugating enzyme E2L 3 | UBE2L3 | 144 | −0.33 | 0.11 | 1.68 × 10−3 | 5.18 × 10−2 | −44.2 | 4507789 |
| Component of oligomeric golgi complex 3 | COG3 | 215 | −0.31 | 0.09 | 1.76 × 10−3 | 5.30 × 10−2 | −35.8 | 13899251 |
| Lipopolysaccharide binding protein | LBP | 500 | −0.49 | 0.24 | 2.09 × 10−3 | 5.73 × 10−2 | −28.4 | 31652249 |
| Complement component 9 | C9 | 500 | −0.49 | 0.24 | 2.32 × 10−3 | 6.26 × 10−2 | −38.6 | 4502511 |
| Inter-alpha-trypsin inhibitor heavy chain family, member 4 | ITIH4 | 500 | −0.49 | 0.24 | 3.12 × 10−3 | 8.03 × 10−2 | −58.1 | 31542984 |
| Mitogen-activated protein kinase kinase kinase 14 | MAP3K14 | 307 | −0.50 | 0.25 | 3.14 × 10−3 | 8.03 × 10−2 | −28.4 | 115298645 |
| Lysozyme | LYZ | 493 | −0.49 | 0.24 | 3.74 × 10−3 | 9.25 × 10−2 | −34.6 | 4557894 |
Twenty proteins quantified by mass spectrometry and estimated by linear mixed effects (LME) modelling in >10% of the samples that were negatively correlated with plasma log2 β-cryptoxanthin (p < 0.01, q < 0.10), listed in increasing order of q, defined as negatively associated protein biomarkers of a plasma β-cryptoxanthin.
n represents the number of child plasma samples in which a protein was detected and quantified by iTRAQ MS (excludes subsequent imputations required for multivariable LME models).
b1 represents the percent change in plasma β-cryptoxanthin (in μmol/L) per 2-fold (100%) increase in protein relative abundance.
GenInfo Identifier sequence number, as assigned to all nucleotide and protein sequences by the National Center for Biotechnology Information at the National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.