Fig. 2.

Log2-normalized expression of Csf1r, Grn, Trem2, Tyrobp, and Aif1 in HOTASTPM mice and related Aβ plaque pathology. (A–B) Log2-normalized expression of Csf1r, Grn, Trem2, Tyrobp and Aif1 in HOTASTPM mice (homozygous for the Swedish mutation APP p.K670N/M671L and PSEN1 p.M146V) at 4 different time points (2, 4, 8, and 18 months) in the hippocampus (A) and cortex (B) showing coexpression of the above genes. (C–D) Progression of AD pathology in hippocampus (C) and cortex (D), based on Aβ plaque density, in HOTASTPM mice at 4 different time points (2, 4, 8, and 18 months). Significant Csf1r, Grn, Trem2, Tyrobp, and Aif1 overexpression (Log2FC > 1, adj. p-value < 0.05) is detected at 8 months, in linear correlation with the most rapid and severe Aβ plaque deposition. Abbreviations: Aβ, amyloid beta; AD, Alzheimer's disease.

Raw data are taken from http://www.mouseac.org/