Supplementary Fig. S2.

(A) 5′UTR length of the studied adult-onset leukodystrophy genes. TREX1 presents the longest 5′UTR region (628nts). (B) TREX1 displays analogous 5′UTR features of BACE1, known to be subjected to translational control: (1) 5′UTR length (628 and 453 nts, respectively); (2) GC content (65% and 77%, respectively), and (3) predicted open reading frames (ORFs) (6 and 3, respectively). (CI–IV) Cortical histological sections of APPPS1 and WT mice (aged 2 months), stained with TREX1 antibody (Abnova 68191), which mainly binds to endothelial cells and to a lesser extent neurons. No macroscopical difference has been detected between APPPS1 and WT mice. Abbreviation: WT, wild type.