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. 2018 Mar 22;410(14):3253–3264. doi: 10.1007/s00216-018-0991-0

Scheme 1.

Scheme 1

Suggested ET mechanism of the oxidation reaction of FDH. D-(–)-fructose is oxidized to 5-keto-D-(–)-fructose releasing two electrons, which are transferred one by one initially through the FAD, followed by two heme c working as monoelectronic acceptors