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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Biochemistry. 2017 Aug 1;56(32):4244–4255. doi: 10.1021/acs.biochem.7b00348

Figure 6. Antifungal susceptibility assay of C. albicans against Hist-5 in metal-supplemented and depleted growth conditions.

Figure 6

Growth inhibition, as measured by OD600 readings after 48 h in YPD medium at 30 °C of C. albicans that had been previously exposed for 1.5 h to: a) increasing concentrations of Hist-5 alone or in combination with CuSO4, FeCl3, BCS, or EDTA at indicated concentrations. Supplemental Cu enhanced the antifungal activity of Hist-5, whereas Fe(III) and metal chelators (BCS, EDTA) decreased it. b) Contrasting effects of supplemental Cu(II) and Fe(III) on C. albicans % Growth upon 6.2 µM Hist-5 treatment are apparent at low µM concentrations.