Table 2.

Univariate and Multivariate Analysis of Risk Factors for CRE Colonization and Mortality.

Variables	CAD HR(95% CI)/pvalue	CIH HR(95% CI)/p value	CRE-RM HR(95% CI)/ p value	IRM HR(95% CI)/p value
Age	0.99(0.98–1.01) /0.94	0.99(0.98–1.01) / 0.94	1.0(0.98–1.04) / 0.20	1.0(0.98–1.03) / 0.40
Gender	0.73(0.36–1.3)/ 0.39	0.76(0.37–1.5) / 0.45	0.41(0.11–1.4) / 0.17	0.57(0.20–1.6) / 0.3
AL	1.85(1–3.5) /0.05	2.2(1.1–4.3) / 0.02 *0.60 (0.17–2.12)/ 0.43	2.3(0.84–6.6) / 0.1	2.8(1.1–7.3) / 0.03 *1.08 (0.23–4.9)/ 0.92
AML	1.89(0.95–3.78)/0.07	2.85(1.4–5.6)/ 0.003 *0.31 (0.07–1.35) /0.11	2.80(1.0–7.7)/0.04 *1.48(0.42–5.17)/ 0.54	4.0(1.6–10.0)/ 0.002 *2.23(0.47–10.74)/0.31
CCI	1.26(0.94–1.7)/0.11	0.81(0.62–1.0)/0.15	1(0.64–1.52)/0.97	1.01(0.69–1.48)/0.94
PS	1.23(0.89–1.71)/0.22	0.79(0.56–1.1)/ 0.16	1.42(0.85–2.39)/0.18	1.4(0.88–2.20)/0.15
Hospital stay	-	1.23(1.16–1.31)/0.0001 *4.3(2.5–8.9) / 0.0001	1.06(1.03–1.1)/0.0001 *1.0(0.96–1.04) / 0.88	1.07(1.04-.10)/0.0001 *1.01(0.97–1.05) / 0.61
CAD	-	-	0.79(0.22–2.9) / 0.73	1.12(0.4–3.2) / 0.82
CIH	-	-	25.6(6.9–94.4) / 0.0001 *22(4.58–106.0) / 0.0001	20.4(6.8–50.5) / 0.0001 *13.9(3.43–56) / 0.0001

Abbreviations: AL: Acute Leukemia; AML: Acute Myeloid Leukemia, CCI: Charlson Comorbidity Index; CRE: Carbapenem Resistant Enterobacteriaceae; CAD: CRE at diagnosis; CIH-CRE in hospital; CRE-RM: CRE related mortality; IRM-Infection related mortality; PS-performance status.

^*indicates multivariate analysis.