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. 2018 Apr 20;50(4):38. doi: 10.1038/s12276-018-0053-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 4 — LJ-2698 (10 mg/kg) was administered in db/db mice and age-matched control db/m mice for 12 weeks. Losartan (1.5 mg/kg) was administered in diabetic mice to compare with the effect of LJ-2698. After 12 weeks of treatment, urine and plasma were collected for analysis of (a) urinary albumin, (b) plasma cystatin C, and (c) urinary KIM-1. Paraffin-embedded kidney sections were stained with (d) PAS staining and (e) nephrin antibody. The scale bar indicates 10 μm, original magnification was ×630. Quantitative analysis of (f) glomerular volume, (g) FMA, and (h) glomerular nephrin area are depicted. Data are presented as the mean ± SE of 7–10 mice/group. *p < 0.05 vs. db/m and ^†p < 0.05 vs. db/db mice