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. 2018 Apr 20;50(4):38. doi: 10.1038/s12276-018-0053-x

Fig. 5. LJ-2698 inhibited kidney fibrosis in db/db mice.

Fig. 5

mRNA expression levels of (a) type IV collagen, (b) PAI-1, and (c) TGF-β were determined by qRT-PCR. Representative photomicrographs of (d) picrosirius red-stained kidney sections are displayed. The scale bar indicates 50 μm; the original magnification was ×100. Quantitative analysis of (e) picrosirius red in kidney cortex is depicted. CM control mice; DM db/db diabetic mice. Data are presented as the mean ± SE of 7–10 mice/group. *p < 0.05 vs. db/m, †p < 0.05 vs. db/db, and #p < 0.05 vs. db/db + LJ-2698