Fig. 6. LJ-2698 ameliorated kidney inflammation in db/db mice.

After 12 weeks of LJ-2698 administration to db/db mice, mRNA expression of inflammatory cytokines in the kidney tissue was measured. (a) MCP-1 and (b) TNF-α mRNA expression was analyzed by qRT-PCR. Paraffin-embedded kidney sections were stained with (c) F4/80 antibody. The scale bar indicates 20 μm; the original magnification was ×200. Quantitative analysis of (d) F4/80 positive stained area is depicted. CM control mice; DM db/db diabetic mice. Data are presented as the mean ± SE of 7–10 mice/group. *p < 0.05 vs. db/m and ^†p < 0.05 vs. db/db mice